These results suggested that c9,t11-CLA induced an insulin-independent enhancement of glucose and fatty acid metabolism. However, c9,t11-CLA did not affect protein kinase B/Akt (Akt). c9,t11-CLA also up-regulated the levels of phosphorglycogen synthase, phosphoracetyl CoA carboxylase, and carnitine palmitoyltransferase-1 while down-regulating the level of pyruvate dehydrogenase kinase 4 under insulin-stimulated and basal conditions. This study was performed with a palmitate-induced IR model using C 2C 12 myotubes and showed that c9,t11-CLA increased insulin-stimulated and basal (non-insulin-stimulated) glucose uptake of IR myotubes. This study is to investigate the IR attenuating effect and the molecular mechanism of cis-9, trans-11-conjugated linoleic acid (c9,t11-CLA). Obesity is a key risk factor in the development of insulin resistance (IR).
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |